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[An improved novel method of venlafaxine synthesis]
Rong Sheng1, Tao Liu, Yong-zhou Hu
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
Abstract
Objective:
To synthesize venlafaxine with an improved novel method.
Methods:
p-methoxypheny lethyl-acid was reacted with SOCl(2) to produce acyl chloride which was reacted with N,N-dimethylamine solution to get amide; then through Ivanov reaction and reduction by KBH(4)/BF(3).Et(2)O to yield venlafaxine.
Result:
Venlafaxine was successfully synthesized by using this method with an yield rate of 50.3%.
Conclusion:
The improved method is suitable for industrial production of venlafaxine.