Peritoneal fluid concentrations of epithelial neutrophil-activating peptide-78 correlate with the severity of
Nobuhiro Suzumori1, Kinue Katano, Kaoru Suzumori
1Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medicine, Nagoya, Japan. og.n.suz@med.nagoya-cu.ac.jp
Objective:
To assess the release of epithelial neutrophil-activating peptide-78 (ENA-78) into peritoneal fluid in women with and without endometriosis.
Design:
Retrospective study.
Setting:
Nagoya City University Hospital.
Patient(S):
Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 59 women with (n = 35) and without (n = 24) endometriosis.
Intervention(S):
Peritoneal fluid samples were obtained at laparotomy or laparoscopy.
Main Outcome Measure(S):
The ENA-78 concentrations in the peritoneal fluid were measured using enzyme-linked immunosorbent assay (ELISA).
Result(S):
The concentrations of ENA-78 in the peritoneal fluid were markedly elevated in the endometriosis patients as compared with the controls, especially in women with severe stage disease.
Conclusion(S):
We conclude that ENA-78 is an important factor that may contribute to the pathogenesis of endometriosis, possibly promoting neovascularization.
