Related Experiment Video

Updated: Aug 26, 2026

Establishment of an Embryo Implantation Model In Vitro
05:13

Establishment of an Embryo Implantation Model In Vitro

Published on: June 21, 2024

[The role of HLA-G expression in the embryo during implantation]

P Le Bouteiller1

  • 1Inserm U563, Centre de Physiopathologie de Toulouse-Purpan, Hôpital Purpan, Toulouse, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|February 18, 2004
PubMed

HLA-G is a non-classical major histocompatibility complex class I molecule, whose tissue distribution is mainly restricted to the placenta. HLA-G expression in the placenta is found mainly in extravillous cytotrophoblast that invades décidual tissue and maternal spiral arteries as well as villous cytotrophoblast (soluble form). Its function contributes to modulate local placental immunity during pregnancy: it is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. HLA-G also modulates cytokine secretion of NK cells upon interaction with specific receptors. Soluble HLA-G1 may also contribute to the control of implantation.

More Related Videos

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis10:13

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis

Published on: March 13, 2026

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

Related Concept Videos

Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...