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Updated: Aug 26, 2026

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
Published on: December 8, 2016
[Rational use of blood cell products in orthopedics and traumatology]
1Department für Orthopädie und Traumatologie, Klinik für Orthopädie des Klinikums der Albert-Ludwigs-Universität Freiburg. KNOELLER@CH11.UKL.UNI-FREIBURG.DE
Study Design:
The risk of transmission of human immunodeficiency virus (HIV), hepatitis B and C viruses as well as the development of costs has changed the use of homologous blood cell products.
Methods:
The present investigation shows the state of the art of blood salvage in orthopedic and elective trauma surgery.
Results:
In this investigation the established methods such as controlled hypotension (spine surgery), arrest of blood supply (extremity surgery) and the following methods of autotransfusion have been examined: acute normovolemic hemodilution (ANH), intra- (Cell-Saver, Haemonetics Corp.) and postoperative autotransfusion, autologous donor plasmapheresis and autologous predeposit.
Conclusions:
Using this method it is possible to reduce homologous blood transfusions particularly in elective procedures such as orthopedic surgery and elective trauma surgery to a minimum.
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