Related Experiment Video

Updated: Aug 26, 2026

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
05:21

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection

Published on: August 14, 2019

Every nose counts: a new influenza vaccine for all healthy schoolchildren?

Manjusha J Gaglani1, Gayla B Herschler

  • 1Section of Pediatric Infectious Diseases, Scott & White Memorial Hospital/Clinic, Scott, Sherwood and Brindley Foundation, Texas A&M University System Health Science Center College of Medicine, Temple, Texas 76508, USA.

Clinical Pediatrics
|February 19, 2004
PubMed

Insights

Vaccinating healthy schoolchildren against influenza can prevent widespread epidemics. This approach aims to limit virus transmission, benefiting both children and the wider community by reducing winter outbreaks.

Area of Science:

  • * Public Health and Epidemiology
  • * Vaccinology and Immunology

Background:

  • * Influenza is a contagious respiratory illness that spreads easily in school settings.
  • * School-aged children are significant vectors for influenza transmission to families and communities.
  • * Uncontrolled winter epidemics pose a substantial public health burden.

Purpose of the Study:

  • * To evaluate the potential public health impact of vaccinating schoolchildren against influenza.
  • * To determine if protecting healthy children can limit influenza spread and reduce societal impact.

Main Methods:

  • * Review of influenza transmission dynamics in school settings.
  • * Assessment of an investigational live-attenuated, cold-adapted, trivalent influenza vaccine.
  • * Analysis of vaccine efficacy in healthy children and adults aged 5–49 years.

Main Results:

  • * The investigational vaccine was approved by the FDA for licensure.
  • * The vaccine targets prevention of influenza in healthy individuals aged 5–49.
  • * Schoolchildren represent a key demographic for influenza transmission control.

Conclusions:

  • * Protecting schoolchildren against influenza is a viable strategy to curb community-wide spread.
  • * Widespread vaccination in schools can mitigate winter influenza epidemics.
  • * This intervention offers significant societal benefits by reducing disease burden.

More Related Videos

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers06:34

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

Measuring Influenza Neutralizing Antibody Responses to A(H3N2) Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells12:09

Measuring Influenza Neutralizing Antibody Responses to A(H3N2) Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells

Published on: November 22, 2017

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.