A randomised controlled study of four-layer compression versus Unna's Boot for venous ulcers

Area of Science:

• Vascular Surgery
• Wound Healing
• Dermatology

Background:

• Venous leg ulcers represent a significant challenge in wound care.
• Traditional treatments like Unna's Boot have been widely used.
• Novel multi-layer compression systems offer potential improvements.

Purpose of the Study:

• To compare the efficacy of Profore (a four-layer bandage system) versus Unna's Boot in treating venous leg ulcers.
• To evaluate healing rates, handling properties, and patient comfort between the two treatment modalities.
• To assess the time to healing and pain experienced by patients in both groups.

Main Methods:

• A prospective, randomized, parallel-group trial was conducted across four Italian centers.
• Patients with venous leg ulcers were randomized to receive either Unna's Boot or Profore treatment.
• Healing was monitored for up to 24 weeks, with pain assessed via a visual analogue scale.

Main Results:

• Complete healing at 24 weeks was observed in 74% of the Profore group versus 66% in the Unna's Boot group.
• No significant difference was found in the time to wound closure between the two treatment groups (p = 0.13).
• Profore applications were rated higher for overall quality and ease of application compared to Unna's Boot.

Conclusions:

• The four-layer bandage system, Profore, is as effective as Unna's Boot for treating venous leg ulcers.
• Both systems provide comparable healing rates and time to closure.
• Profore may offer advantages in terms of ease of application and bandage appearance.