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Published on: November 9, 2018
The French early arthritis registry
1Service d'Immuno-Rhumatologie, Hôpital Lapeyronie, 34295 Montpellier, France.
Clinical and Experimental Rheumatology
|February 19, 2004
Summary
Early rheumatoid arthritis (RA) patients' joint damage progression is predicted by baseline radiographic scores and inflammatory markers. Disability in early RA is linked to disease activity, including the Health Assessment Questionnaire (HAQ) score.
Area of Science:
- Rheumatology
- Clinical Epidemiology
Background:
- Two French multicenter cohorts of early rheumatoid arthritis (RA) patients were established.
- A community-based study initiated in 1993 aimed to identify prognostic factors for RA.
- The ESPOIR cohort study is a large national registry for early inflammatory arthritis.
Purpose of the Study:
- To identify prognostic factors for joint destruction, disability, and remission in early RA.
- To describe the objectives, design, and organization of the ESPOIR early arthritis registry.
- To establish a database for investigating diagnostic, prognostic, etiologic, pathogenic, and medico-economic factors in early inflammatory arthritis.
Main Methods:
- Analysis of a community-based cohort started in 1993.
- Reporting of 3-year and 5-year results from the initial cohort.
- Description of the design and organization of the ESPOIR cohort study.
Main Results:
- Radiographic scores, ESR, CRP, rheumatoid factor, and DRB1*04 genes predicted joint damage progression at baseline.
- Disease activity, including the HAQ score, predicted disability.
- The ESPOIR cohort serves as a database for multiple research investigations.
Conclusions:
- Baseline factors effectively predict joint damage and disability in early RA.
- The ESPOIR cohort provides a valuable resource for comprehensive research on early inflammatory arthritis.
- Further research can leverage these cohorts to understand RA etiology, pathogenesis, and management.
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