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Updated: Aug 26, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
[The usefulness of lymphocyte stimulation test (LST) in side effects of antituberculosis drugs]
Shuichi Yano1, Kanako Kobayashi, Kazuhiro Kato
1Department of Pulmonary Medicine, National Matsue Hospital, 5-8-31, Agenogi, Matsue-shi, Shimane 690-8556, Japan. yano@matsue.hosp.go.jp
Purpose:
The usefulness of the lymphocyte stimulation test (LST) was examined in patients who arose side effects to antituberculosis drugs.
Methods:
The usefulness of LST was examined in 36 patients from January, 1999 to July, 2002.
Results:
There were 11 LST positive patients, and the LST positive rate was 30.6%. The causing agents determined by the LST positive patients were INH in 7, RFP in 3 and EB in one. The sensitivity of LST was 46.2% and the specificity of LST was 76.6%.
Conclusion:
LST positive rate of antituberculosis drugs was low and it was difficult to determine the causing drugs by LST.
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