[The influence of prostaglandins on metastases development]

Arachidonic acid metabolites including prostaglandins (PG) participate in many biological processes and play regulatory functions. The significant role of PG in physiological and pathological process is well known and described by many authors. Prostaglandins were demonstrated to have local hormone properties and often exert an antagonist effect. Despite years of research the role of PG in cancer diseases development is still poorly understood. The article is focused on the influence of arachidonic acid metabolites and its analogs on tumor growth and metastases formation.