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Drug dosing during intermittent hemodialysis and continuous renal replacement therapy : special considerations in

Michael A Veltri1, Alicia M Neu, Barbara A Fivush

  • 1Pediatric Division, Department of Pharmacy, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-6180, USA. mveltri@jhmi.edu

Paediatric Drugs
|February 19, 2004
PubMed

Insights

Managing drug therapy in pediatric patients with acute or chronic renal failure is crucial. This review focuses on drug dosing for children undergoing intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT).

Area of Science:

  • Pediatric Nephrology
  • Clinical Pharmacology
  • Intensive Care Medicine

Background:

  • Acute renal failure is more common than chronic renal failure in children.
  • Children with renal failure often have comorbid conditions requiring medication.
  • Renal replacement therapy (RRT) is frequently needed for pediatric patients with renal failure.

Purpose of the Study:

  • To summarize drug pharmacokinetics and dosing in pediatric patients undergoing RRT.
  • To provide guidance on managing drug therapy for children on intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT).
  • To highlight the importance of awareness among healthcare professionals regarding drug management in pediatric RRT.

Main Methods:

  • Review of pharmacokinetics and dosing of commonly prescribed drugs for pediatric patients.
  • Focus on drug management in pediatric patients undergoing IHD and CRRT in intensive care units.
  • Exclusion of peritoneal dialysis from the review.

Main Results:

  • Summarizes drug pharmacokinetics and dosing for pediatric patients on IHD and CRRT.
  • Provides a table of recommended initial dosages for commonly encountered drugs.
  • Highlights the complexities of drug therapy in critically ill children with renal failure.

Conclusions:

  • Accurate drug dosing is essential for pediatric patients undergoing IHD and CRRT.
  • Healthcare providers must be knowledgeable about drug management in this population.
  • This review serves as a valuable resource for optimizing pharmacotherapy in pediatric renal failure.

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