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Impact of strut thickness on late luminal loss after coronary artery stent placement
Saskia Z H Rittersma1, Robbert J de Winter, Karel T Koch
1Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
Insights
Thinner coronary artery stent struts (50 microm) significantly reduced late luminal loss compared to thicker struts (≥90 microm). Strut thickness is an independent predictor of late luminal loss after stenting.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomedical Engineering
Background:
- Coronary artery disease necessitates stenting to restore blood flow.
- Stent design, particularly strut thickness, may influence long-term outcomes.
- Late luminal loss is a key metric for assessing in-stent restenosis and stent performance.
Purpose of the Study:
- To investigate the impact of coronary artery stent strut thickness on angiographic late luminal loss.
- To determine if stent strut thickness is an independent predictor of late luminal loss.
Main Methods:
- Single-center observational cohort study.
- Inclusion of 663 patients receiving ACS Multilink stents in native coronary vessels.
- Angiographic follow-up at 6-10 months to measure late luminal loss.
Main Results:
- Patients treated with thin-strut stents (50 microm) showed significantly less late luminal loss (0.92 ± 0.59 mm) than those with thick-strut stents (≥90 microm) (1.06 ± 0.71 mm).
- Multivariate regression analysis identified strut thickness as an independent predictor of late luminal loss (p=0.011).
Conclusions:
- Coronary artery stent strut thickness is a significant factor influencing late luminal loss.
- Thinner strut stents are associated with better angiographic outcomes, reducing late luminal loss.
- These findings support the consideration of strut thickness in stent selection for coronary interventions.
Abstract:
To determine the influence of coronary artery stent strut thickness on angiographic late luminal loss, 663 patients were included in a single-center observational cohort after receiving an ACS Multilink stent in a native coronary vessel. At 6- to 10-month follow-up, 287 patients treated with a thin-strut stent (50 microm) had significantly less late luminal loss than 376 patients treated with a thick-strut stent (> or =90 microm) (mean 0.92 +/- 0.59 vs 1.06 +/- 0.71 mm, p = 0.011); on multivariate regression analysis, strut thickness was found to be an independent predictor for late luminal loss.
