Purification and identification of protein complexes that control the cell cycle

Dual FAK and EPHA2 targeting by brigatinib tackles PARP inhibitor adaptive survival response in high-grade serous ovarian cancer.

Science translational medicine·2026

Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors.

Nature cancer·2023

DAGBagM: learning directed acyclic graphs of mixed variables with an application to identify protein biomarkers for treatment response in ovarian cancer.

BMC bioinformatics·2022

A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides.

Chemical science·2022

Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress.

The Journal of biological chemistry·2022

Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.

Cell reports. Medicine·2022

Integrating AI-Based Protein Modeling and Fragment Molecular Orbital Analysis for Structure-Based Drug Design.

Methods in molecular biology (Clifton, N.J.)·2026

Fragment Molecular Orbital Drug Design Consortium (FMODD): Bridging Academia and Industry Through Prospective FMO-Driven Drug Design.

Methods in molecular biology (Clifton, N.J.)·2026

How Can QM Methods Be Used to Guide Synthesis Planning in Drug Discovery?

Methods in molecular biology (Clifton, N.J.)·2026

Fragment Molecular Orbital-Based Molecular Dynamics (FMO-MD): Current Status and Challenges.

Methods in molecular biology (Clifton, N.J.)·2026

HessFit: Deriving Molecule-Specific Force Fields from Quantum Mechanical Hessians.

Methods in molecular biology (Clifton, N.J.)·2026

Integration of GPCR Modeling with QM for Drug Design: Academic and Industry Collaboration.

Methods in molecular biology (Clifton, N.J.)·2026

High-Ratio Partial Proteolysis with Carrier Proteome (HOLSER) Enables Global Structure Profiling and Site-Resolved Elucidation of Ligand-Protein Interactions.

Analytical chemistry·2026

Quantitative Kinetic Analysis of Protein-Phosphoinositide Binding by Optimized Liposome-Based Bio-Layer Interferometry.

Biochemistry·2026

Extracellular vesicles and acetylation: reciprocal regulation in disease progression.

Frontiers in immunology·2026

Seminal exosome protection of frozen human spermatozoa: homologous versus heterologous treatment.

Reproductive biomedicine online·2026

Untangling the Complexity of Binding Across Biomolecular Interfaces with Interaction Network Models.

Methods in molecular biology (Clifton, N.J.)·2026

Unveiling the post-translational landscape of Claudins: Orchestrators of barrier integrity, signaling, and disease through dynamic modifications.

International journal of biological macromolecules·2026

Related Experiment Videos

Purification and identification of protein complexes that control the cell cycle

Related Concept Videos

Dual FAK and EPHA2 targeting by brigatinib tackles PARP inhibitor adaptive survival response in high-grade serous ovarian cancer.

Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors.

DAGBagM: learning directed acyclic graphs of mixed variables with an application to identify protein biomarkers for treatment response in ovarian cancer.

A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides.

Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress.

Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.

Integrating AI-Based Protein Modeling and Fragment Molecular Orbital Analysis for Structure-Based Drug Design.

Fragment Molecular Orbital Drug Design Consortium (FMODD): Bridging Academia and Industry Through Prospective FMO-Driven Drug Design.

How Can QM Methods Be Used to Guide Synthesis Planning in Drug Discovery?

Fragment Molecular Orbital-Based Molecular Dynamics (FMO-MD): Current Status and Challenges.

HessFit: Deriving Molecule-Specific Force Fields from Quantum Mechanical Hessians.

Integration of GPCR Modeling with QM for Drug Design: Academic and Industry Collaboration.

High-Ratio Partial Proteolysis with Carrier Proteome (HOLSER) Enables Global Structure Profiling and Site-Resolved Elucidation of Ligand-Protein Interactions.

Quantitative Kinetic Analysis of Protein-Phosphoinositide Binding by Optimized Liposome-Based Bio-Layer Interferometry.

Extracellular vesicles and acetylation: reciprocal regulation in disease progression.

Seminal exosome protection of frozen human spermatozoa: homologous versus heterologous treatment.

Untangling the Complexity of Binding Across Biomolecular Interfaces with Interaction Network Models.

Unveiling the post-translational landscape of Claudins: Orchestrators of barrier integrity, signaling, and disease through dynamic modifications.

Related Experiment Videos

Purification and identification of protein complexes that control the cell cycle

Related Concept Videos

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