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Chicken genome sequence: a centennial gift to poultry genetics.
1Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 488242-4320, USA. dodgson@msu.edu
Cytogenetic and Genome Research
|February 19, 2004
Summary
The chicken genome sequence is nearing completion, marking a new era in poultry genetics. This advancement will integrate agricultural applications with model species research through comparative genomics.
Area of Science:
- Genomics
- Animal Genetics
- Bioinformatics
Background:
- The chicken genome sequence is anticipated by early 2004, coinciding with the centenary of poultry genetics.
- The first century of poultry genetics was marked by the use of chickens to demonstrate Mendelian inheritance.
Purpose of the Study:
- To outline the transition from classical poultry genetics to the post-genomic era.
- To project the future impact of the chicken genome sequence on research and agriculture.
Main Methods:
- Whole genome shotgun (WGS) sequencing approach for approximately six-fold genome coverage.
- Integration of bacterial artificial chromosome (BAC) and fosmid end sequences.
- Assembly of WGS data using BAC contig maps, genetic linkage, and radiation hybrid maps.
Main Results:
- The draft chicken genome sequence is nearing completion.
- Advancements in global analysis of chicken gene expression patterns are underway.
- Comparative genomics will facilitate integration of chicken data with other animal species.
Conclusions:
- The chicken genome sequence is expected to unify studies of the chicken as a model organism and for agricultural applications.
- The post-genomic era promises significant advancements in poultry genetics.
- Comparative genomics will be crucial for leveraging the chicken genome sequence.