Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis in cancer--implications for therapy.

Henning Schulze-Bergkamen1, Peter H Krammer

  • 1Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany.

Seminars in Oncology
|February 19, 2004
PubMed
Summary

Cancer cells survive by resisting apoptosis, or programmed cell death. Understanding and targeting apoptosis pathways is crucial for developing effective cancer treatments and overcoming drug resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical practice and implications of biomarker testing in biliary tract cancer: An observational study.

JHEP reports : innovation in hepatology·2026
Same author

A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy.

International journal of molecular sciences·2025
Same author

Correction: Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications.

Breast cancer research : BCR·2024
Same author

Etiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC.

Hepatology (Baltimore, Md.)·2023
Same author

Dimethyl fumarate treatment in relapsed and refractory cutaneous T-cell lymphoma: a multicenter phase 2 study.

Blood·2023
Same author

Molecular analysis of Annexin expression in cancer.

BMC cancer·2022

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Resistance to apoptosis is a hallmark of malignant cells, enabling uncontrolled proliferation and survival.
  • Defects in apoptosis signaling pathways contribute significantly to tumor cell drug resistance.
  • Targeting apoptosis is a key strategy in cancer therapy to eliminate malignant cells.

Purpose of the Study:

  • To review the role of apoptosis signaling in cancer development (tumorigenesis).
  • To examine the contribution of apoptosis defects to cancer drug resistance.
  • To discuss therapeutic strategies that modulate apoptosis pathways for cancer treatment.

Main Methods:

  • Literature review of scientific articles on apoptosis, tumorigenesis, and cancer therapy.
  • Analysis of the molecular mechanisms underlying apoptosis resistance in cancer.
  • Synthesis of current knowledge on therapeutic interventions targeting apoptosis.

Main Results:

  • Apoptosis resistance is essential for cancer cell survival and progression.
  • Dysregulation of apoptosis pathways is a common mechanism of chemoresistance.
  • Targeting apoptosis offers promising therapeutic avenues in oncology.

Conclusions:

  • Modulating apoptosis is a critical goal for overcoming cancer and drug resistance.
  • Translating knowledge of apoptosis pathways into clinical practice is a key challenge in oncology.
  • Further research into apoptosis-targeting therapies holds significant potential for improving cancer treatment outcomes.

Related Experiment Videos