Related Experiment Video
Updated: Aug 26, 2026
Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 8, 2024
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study
Lawrence R Robinson1, Joseph M Czerniecki, Dawn M Ehde
1Department of Rehabilitation Medicine, University of Washington, Seattle 98104, USA. lorenzo@u.washington.edu
Objective:
To evaluate whether amitriptyline is more effective than placebo in improving phantom limb pain or residual limb pain.
Design:
Randomized controlled trial of amitriptyline for 6 weeks.
Setting:
University hospital.
Participants:
Thirty-nine persons with amputation-related pain lasting more than 6 months.
Intervention:
Six-week trial of amitriptyline (titrated up to 125 mg/d) or an active placebo (benztropine mesylate).
Main Outcome Measures:
Analyses were conducted to examine whether there was a medication group effect on the primary outcomes (average pain intensity) and secondary outcome measures (disability, satisfaction with life, handicap).
Results:
No significant differences were found between the treatment groups in outcome variables when controlling for initial pain scores.
Conclusions:
Our findings do not support the use of amitriptyline in the treatment of postamputation pain.
More Related Videos
03:53Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 15, 2024
08:33A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
Published on: January 5, 2024