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Updated: Sep 9, 2026
Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
Published on: December 7, 2011
Relationship between regional bone density measurements and the time since injury in adults with spinal cord injuries
Jody L Clasey1, Adrienne L Janowiak, David R Gater
1Department of Kinesiology and Health Promotion, University of Kentucky, Lexington 40506-0219, USA. jlclas0@pop.uky.edu
Objectives:
To determine the bone mineral density (BMD) of the legs, arms, and trunk region of a group of adults with spinal cord injury (SCI) and to determine the relationship between regional BMD values and the time since injury.
Design:
BMD measurements were determined by total-body, dual-energy x-ray absorptiometry scans and percentage values (percentage-matched BMD), based on manufacturer-supplied normative data for age, sex, body weight, and ethnic group. The relationship between percentage-matched BMD values and time since injury was determined by linear regression analyses.
Setting:
Research laboratories in a university setting.
Participants:
Twenty-nine subjects (21 men, 8 women; mean age, 38.5 y) who had sustained an SCI a mean of 10.6 years earlier (range, 0.6-35.3 y).
Interventions:
Not applicable.
Main Outcome Measures:
The relationship between percentage-matched BMD values and the time since injury.
Results:
There was a significant inverse relationship between percentage-matched BMD leg (r2 = -.76), arm (r2 = -.45), and trunk (r2 = -.38) values and the log of time since injury.
Conclusion:
Despite the varying levels of SCI and other relevant BMD contributing factors, the regional percentage-matched BMD values were significantly inversely related to the log of time since injury.
