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Genetic Analysis Workshop II: further consideration of segregation and linkage analyses in Problem 3
P L Kramer1, D B Altmann, K K Kidd
1Department of Human Genetics, Yale Univeristy School of Medicine, New Haven , Connecticut.
Abstract:
We analyzed disease-marker associations in Problem 3 for the Genetic Analysis Workshop II, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 1984]. Certain features that we added to the running of LIPED to facilitate the analysis are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker-trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.
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