Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Impaired angiogenesis in the aged.

May J Reed1, Jay M Edelberg

  • 1Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98104, USA. mjr@u.washington.edu

Science of Aging Knowledge Environment : SAGE KE
|February 20, 2004
PubMed
Summary

Aging impairs angiogenesis, the formation of new blood vessels. This perspective details age-related changes in angiogenesis and its effects on wound healing, vascular disease, and cancer in older individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of Tonlamarsen in Patients With Uncontrolled Hypertension: The KARDINAL Phase 2 Randomized Clinical Trial.

Journal of the American College of Cardiology·2026
Same author

Lecanemab alters basement membrane collagen IV in viable microvessels isolated from brains with high Alzheimer's disease neuropathology.

Journal of Alzheimer's disease : JAD·2026
Same author

Comparative permeability of the blood-brain barrier to albumin, DTPA, and sucrose: effects of inflammation-induced disruption.

Fluids and barriers of the CNS·2025
Same author

Transport of CCL2 across an induced pluripotent stem cell-derived in vitro model of the human blood-brain barrier is heparan sulfate-dependent.

PloS one·2025
Same author

Danicamtiv, a Selective Agonist of Cardiac Myosin, for Dilated Cardiomyopathy: A Phase 2 Open-Label Trial.

Journal of the American College of Cardiology·2025
Same author

Communication Surrounding Treatment Preferences for Older Adults With Dementia During Emergency Medical Services Response.

Journal of the American Geriatrics Society·2025

Area of Science:

  • Biomedical science
  • Physiology
  • Aging research

Background:

  • Angiogenesis is crucial for tissue repair and maintaining vascular health.
  • Age-associated decline in physiological functions affects the body's ability to form new blood vessels.

Purpose of the Study:

  • To provide a comprehensive overview of age-related alterations in the angiogenic process.
  • To discuss the consequences of impaired angiogenesis in aging.

Main Methods:

  • Review of existing literature on angiogenesis and aging.
  • Analysis of molecular and cellular changes affecting angiogenesis with age.

Main Results:

  • Multiple components of the angiogenic response are significantly altered during aging.
  • Impaired angiogenesis contributes to various age-related pathologies.

Conclusions:

  • Aging profoundly impacts angiogenesis, affecting tissue regeneration and increasing susceptibility to diseases.
  • Understanding these changes is vital for developing interventions for age-related conditions.

Related Experiment Videos