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Single-step fabrication of drug-encapsulated inorganic microspheres with complex form by sonication-induced

Alexander Kulak1, Simon R Hall, Stephen Mann

  • 1School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.

Chemical Communications (Cambridge, England)
|February 20, 2004
PubMed

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...