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The first general method for alpha-trifluoromethylation of carboxylic acids using BrF3
1School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.
Chemical Communications (Cambridge, England)
|February 20, 2004
Abstract:
2-Carbomethoxy-1,1-bis(methylsulfide)-1-alkenes, easily made from carboxylic acids, CS(2) and MeI, were treated with BrF(3) producing eventually the desired alpha-trifluoromethyl carboxylate derivatives--RCH(CF(3))COOR'--in good yields.