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Related Experiment Videos

Nitrates for achalasia.

Z H Wen1, E Gardener, Y P Wang

  • 1Department of Gastroenterology, First University Hospital, West China University at Medical Sciences, Chengdu, China.

The Cochrane Database of Systematic Reviews
|February 20, 2004
PubMed
Summary
This summary is machine-generated.

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Nitrate therapy for achalasia (a disease impairing esophageal motility) lacks sufficient evidence due to limited randomized controlled trials. More research is needed to determine nitrate effectiveness for achalasia treatment.

Area of Science:

  • Gastroenterology
  • Clinical Pharmacology

Background:

  • Achalasia is a disorder affecting esophageal motility.
  • The efficacy of nitrates for achalasia treatment remains controversial despite historical use.

Purpose of the Study:

  • To evaluate the short-term and long-term effectiveness of nitrate therapy in achalasia patients.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) identified through extensive database searches (Cochrane, MEDLINE, EMBASE, LILACS, CBM).
  • Included all RCTs involving achalasia patients treated with any form of nitrates.
  • Data extraction followed the intention-to-treat principle by two independent observers.

Main Results:

  • Two randomized cross-over studies were identified, but they did not provide extractable results.

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  • The study designs and reporting methods prevented the extraction of necessary outcome data.

    • Conclusions:

    • Current evidence is insufficient to guide clinical practice regarding nitrate use in achalasia.
    • There is a need for well-designed, parallel-group randomized controlled trials with long-term follow-up to establish the effects of nitrates.