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Trifluoperazine for schizophrenia.

L O Marques1, M S Lima, B G O Soares

  • 1Psychiatry, Mestrado de Saúde e Comportamento-Universidade Católica de Pelotas, Gonçalves Chaves 962 sala 302, Pelotas, Rio Grande do Sul, Brazil.

The Cochrane Database of Systematic Reviews
|February 20, 2004
PubMed
Summary
This summary is machine-generated.

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Trifluoperazine, an accessible antipsychotic, shows similar efficacy to other neuroleptics for schizophrenia treatment. While effective for global improvement, it may increase movement disorders compared to placebo.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Trials

Background:

  • Trifluoperazine is a widely used, cost-effective, high-potency antipsychotic for schizophrenia and related psychoses.
  • Assessing its comparative efficacy and safety is crucial for clinical practice.

Purpose of the Study:

  • To systematically evaluate the effects of trifluoperazine against placebo and other antipsychotic drugs.
  • To synthesize evidence from randomized controlled trials (RCTs).

Main Methods:

  • Conducted comprehensive searches of the Cochrane Schizophrenia Group's trial register and other sources.
  • Included all eligible randomized clinical trials comparing trifluoperazine with other treatments for schizophrenia.
  • Employed reliable study selection, quality rating, data extraction, and statistical analysis, including intention-to-treat where possible.

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Main Results:

  • Compared to placebo, trifluoperazine demonstrated a small short-term benefit in global improvement (NNT=3) but was associated with increased antiparkinsonian drug use (NNH=4).
  • Against other older antipsychotics, trifluoperazine showed no significant differences in substantial improvement or study withdrawal.
  • Adverse event rates were similar, though trifluoperazine was more likely to cause extrapyramidal symptoms than low-potency antipsychotics (NNH=6).

Conclusions:

  • Trifluoperazine is an effective antipsychotic with efficacy comparable to other commonly used neuroleptics for schizophrenia.
  • Its adverse event profile is similar to other drugs in its class.
  • Evidence supporting claims of trifluoperazine's effectiveness at low doses for schizophrenia is not robust.