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Related Experiment Videos

Interventions for treating collagenous colitis.

N Chande1, J W D McDonald, J K MacDonald

  • 1c/o LHSC-UC, A-LL132, 339 Windermere Road, London, Ontario, CANADA, N6A 5A5.

The Cochrane Database of Systematic Reviews
|February 20, 2004
PubMed
Summary
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Budesonide effectively treats collagenous colitis, showing significant clinical and histological improvement. Bismuth subsalicylate has weaker evidence, and prednisolone shows a trend toward efficacy in limited studies for this chronic diarrhea condition.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Collagenous colitis is a recognized cause of chronic diarrhea.
  • Current treatments rely heavily on anecdotal evidence.
  • A need exists for evidence-based therapeutic strategies.

Purpose of the Study:

  • To identify effective treatments for collagenous colitis.
  • To review therapies supported by randomized controlled trials.

Main Methods:

  • Systematic literature search of MEDLINE, PubMed, and Cochrane databases (1970-2003).
  • Inclusion of five randomized trials evaluating bismuth subsalicylate, prednisolone, and budesonide.
  • Data extraction and analysis using chi-square tests and Peto odds ratios.

Main Results:

Related Experiment Videos

  • Budesonide demonstrated significant clinical and histological improvement (pooled OR 12.32, NNT=2).
  • Bismuth subsalicylate showed significant clinical and histological improvement (p=0.003).
  • Prednisolone showed a trend toward clinical response (p=0.064), with histological effects not studied.

Conclusions:

  • Budesonide is an effective treatment for collagenous colitis.
  • Evidence for bismuth subsalicylate is less robust; prednisolone shows potential but requires further study.
  • The effectiveness of these treatments for remission induction/maintenance remains unknown.