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Gross Rearrangement Breakpoint Database (GRaBD).

Shaun S Abeysinghe1, Peter D Stenson, Michael Krawczak

  • 1Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, United Kingdom. abeysinghe@cardiff.ac.uk

Human Mutation
|February 20, 2004
PubMed
Summary
This summary is machine-generated.

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DNA rearrangements like translocations and deletions cause cancer and inherited diseases. The Gross Rearrangement Breakpoint Database (GRaBD) analyzes these genetic events to understand their causes.

Area of Science:

  • Genetics
  • Genomics
  • Molecular Biology

Background:

  • DNA rearrangements, including translocations and gross gene deletions, are significant contributors to human cancers and inherited diseases.
  • These genomic alterations are not randomly distributed, suggesting underlying biological mechanisms related to DNA sequence susceptibility and selection.
  • Understanding the sequence context of these breakpoints is crucial for deciphering their etiology.

Purpose of the Study:

  • To establish a comprehensive database of DNA rearrangement breakpoints.
  • To analyze the sequence characteristics of translocation and deletion breakpoints.
  • To identify sequence features that predispose DNA to breakage and recombination.

Main Methods:

  • Creation and curation of the Gross Rearrangement Breakpoint Database (GRaBD).

Related Experiment Videos

  • Collection of 397 germline and somatic DNA breakpoint junction sequences.
  • Analysis of breakpoint sequences from 219 distinct human inherited diseases and cancers.

    • Main Results:

    • GRaBD is the sole comprehensive repository of gross gene rearrangement breakpoint junctions.
    • The database facilitates the study of sequence contexts associated with DNA rearrangements.
    • Provides a resource for investigating the nonrandom distribution of genomic alterations.

    Conclusions:

    • The Gross Rearrangement Breakpoint Database (GRaBD) is a valuable resource for studying the molecular basis of DNA rearrangements.
    • Analysis of breakpoint sequences can reveal insights into the mechanisms driving cancer and inherited diseases.
    • GRaBD supports research into sequence-dependent DNA instability and genomic variation.