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[Bone density measurements by computer tomography (author's transl)].

S Lange, T h Weiss, G Gahl

    Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
    |July 1, 1978
    PubMed
    Summary
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    This study validates the E.M.I. mark I computer scanner for bone densitometry. The method accurately quantifies forearm bone mineral density, distinguishing between cortical and spongy bone in various conditions.

    Area of Science:

    • Radiology
    • Medical Imaging
    • Orthopedics

    Background:

    • Bone densitometry is crucial for diagnosing and monitoring bone diseases.
    • Current methods may lack the ability to differentiate between cortical and spongy bone loss.
    • The E.M.I. mark I computer scanner offers potential for advanced bone analysis.

    Purpose of the Study:

    • To evaluate the suitability of the E.M.I. mark I computer scanner for bone densitometry.
    • To assess the quantitative analysis of forearm bone mineral density.
    • To compare bone demineralization patterns in different patient groups.

    Main Methods:

    • Utilized the E.M.I. mark I computer scanner for forearm bone densitometry.
    • Established a linear relationship between CT densities and bone equivalent substance (K2HPO4) concentration.

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  • Developed a computer program for quantitative analysis of cortical and spongiosa bone.
  • Assessed reproducibility with a coefficient of variation of 5%.

    • Main Results:

    • Demonstrated a linear correlation between CT densities and K2HPO4 concentration.
    • Successfully quantified spongiosa and cortex of forearm bones separately.
    • Achieved reproducibility comparable to existing bone densitometry procedures.
    • Identified distinct demineralization patterns in senile and renal osteopathies.

    Conclusions:

    • The E.M.I. mark I computer scanner is suitable for bone densitometry, offering separate analysis of cortical and spongiosa bone.
    • Senile demineralization primarily affects the cortex, while renal osteopathies in dialysis patients predominantly impact the spongiosa.
    • This method provides valuable insights into bone disease pathogenesis and progression.