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Related Experiment Video

Updated: Feb 28, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
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Congenital trigeminal anaesthesia.

S J Hashmi1, G Chow, S B Bittner

  • 1Bassetlaw District General Hospital, Worksop S81 0BD, Nottinghamshire, UK. Shakil38@yahoo.co.uk

Developmental Medicine and Child Neurology
|February 21, 2004
PubMed
Summary
This summary is machine-generated.

Congenital trigeminal nerve anesthesia, a rare condition, presents in two distinct cases: one isolated unilateral and one bilateral with additional neurological issues. These cases highlight the varied presentations and developmental complexities of this nerve disorder.

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Area of Science:

  • Neurology
  • Developmental Biology
  • Genetics

Background:

  • Congenital trigeminal nerve anesthesia is a rare condition characterized by the absence of sensation in the trigeminal nerve distribution from birth.
  • Understanding its etiology is crucial for diagnosis and management, yet the underlying causes remain largely unknown.

Observation:

  • This study describes two pediatric patients diagnosed with congenital trigeminal nerve anesthesia.
  • The first patient, a 14-year-old male, presented with isolated unilateral anesthesia affecting all three trigeminal nerve divisions.
  • The second patient, a 3-year-old male, exhibited bilateral anesthesia across all trigeminal divisions, accompanied by other neurological abnormalities.

Findings:

  • No specific cause was identified for the trigeminal nerve abnormalities in either patient.
  • The cases illustrate the spectrum of congenital trigeminal nerve anesthesia, from isolated sensory loss to complex neurological presentations.
  • The Rosenberg classification is discussed in the context of these patient presentations.

Implications:

  • These cases underscore the need for further research into the developmental biology and potential genetic factors underlying congenital trigeminal nerve anesthesia.
  • Accurate classification and understanding of this condition are essential for appropriate clinical evaluation and potential future therapeutic strategies.
  • Further investigation may elucidate the mechanisms of trigeminal nerve development and sensory pathway formation.