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Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes
12:50

Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes

Published on: August 9, 2011

[Listeriosis in the adult. Revision of 10 cases]

I M Arias Miranda1, F J Nuño Mateo, J Noval Menéndez

  • 1Servicio de Medicina Interna, Hospital de Cabueñes, Gijón, Asturias. ariasmir@yahoo.es

Anales De Medicina Interna (Madrid, Spain : 1984)
|February 21, 2004
PubMed

Insights

Listeria monocytogenes (LM) infections are rare in immunosuppressed patients, often presenting as sepsis or meningitis. This study highlights clinical features and a high mortality rate of 40% in these vulnerable individuals.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Immunocompromised Host

Background:

  • Listeria monocytogenes (LM) is an opportunistic pathogen.
  • Infections in immunosuppressed patients are rare but severe.
  • Understanding clinical-epidemiological and therapeutic characteristics is crucial.

Observation:

  • A study of 10 immunosuppressed patients with LM infections was conducted.
  • Infections presented as primary bacteremia (4), meningeal involvement (3), spontaneous bacterial peritonitis (2), and abdominal access (1).
  • Underlying disorders predisposing to infection were present in all patients.

Findings:

  • Sepsis and meningeal syndrome were the most frequent clinical presentations.
  • Ampicillin was the predominant antibiotic used for treatment.
  • The overall mortality rate associated with LM infection was 40%.

Implications:

  • Early recognition and appropriate management of LM infections are critical in immunosuppressed populations.
  • The high mortality rate underscores the severity of these infections.
  • Further research into optimal therapeutic strategies may improve outcomes.

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