Related Experiment Videos
Comparison of longitudinal variance components and regression-based approaches for linkage detection on chromosome 17
Mariza de Andrade1, Curtis Olswold
1Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, 200 First Street, SW, Rochester, Minnesota, USA. mandrade@mayo.edu
Abstract:
We compare two methods to detect genetic linkage by using serial observations of systolic blood pressure in pedigree data from the Framingham Heart Study focusing on chromosome 17. The first method is a variance components (VC) approach that incorporates longitudinal pedigree data, and the second method is a regression-based approach that summarizes all longitudinal measures in one single measure. No evidence of linkage was found either using the VC longitudinal approach or the regression-based approach, except when all time points were used from Cohorts 1 and 2 and only subjects aged 25 and 75 years were included.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Longitudinal Studies
Variability: Analysis
The range is a simple measure of variability, indicating the difference between the highest and...