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Published on: January 28, 2020
Polymorphism K469E of intercellular adhesion molecule-1 gene and restenosis after coronary stenting in Chinese
Zhao-ping Liu1, Yong Huo, Jian-ping Li
1Department of Cardiology, First Hospital of Peking University, Beijing 100034, China.
Insights
The KK genotype of the Intercellular Adhesion Molecule-1 (ICAM-1) gene K469E polymorphism is linked to a higher risk of restenosis after coronary stenting. This association is particularly strong in patients with obesity or hyperlipemia.
Area of Science:
- Cardiovascular Genetics
- Molecular Biology
- Medical Science
Background:
- Inflammation is a primary driver of restenosis post-coronary stenting.
- Intercellular Adhesion Molecule-1 (ICAM-1) facilitates leukocyte-endothelial adhesion, crucial in inflammatory processes.
- The study investigates the link between ICAM-1 gene K469E polymorphism and restenosis risk.
Purpose of the Study:
- To determine the association between the ICAM-1 K469E polymorphism and restenosis after coronary stenting.
- To evaluate the ICAM-1 K469E polymorphism's role in a North Chinese population undergoing stenting.
Main Methods:
- Genotyping of the ICAM-1 K469E polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
- Analysis of 124 patients with prior coronary stenting and angiography.
- Collection of clinical risk factors and procedure-related data.
Main Results:
- A restenosis rate of 58.1% was observed in the study cohort.
- Significant differences in genotype distribution were found between restenosis and non-restenosis groups (P=0.049).
- KK homozygotes showed a 2.6-fold increased risk (OR=2.6, P=0.018) compared to E allele carriers, with higher odds in obese (OR=9.3) and hyperlipemic (OR=3.7) patients.
Conclusions:
- KK homozygotes of the ICAM-1 codon 469 mutation are associated with increased restenosis risk post-coronary stenting.
- The KK genotype is a significant predictor of restenosis, especially in obese or hyperlipemic individuals.
- These findings highlight the role of ICAM-1 K469E polymorphism in coronary artery disease progression.
Background:
Inflammation is a major cause of restenosis after coronary stenting. Intercellular adhesion molecule-1 (ICAM-1) is an important adhesion molecule that plays a key role in the tight adhesion between leukocytes and vascular endothelium. The object of this study was to investigate the association between the K469E polymorphism of the ICAM-1 gene and restenosis after coronary stenting in North Chinese population.
Methods:
The ICAM-1 K469E polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism method in 124 patients who had undergone coronary stenting and coronary angiography at least 3 months earlier. Information on clinical risk factors and procedure-related data were also collected.
Results:
Of 124 enrolled patients in total, there were 72 cases of in-stent restenosis. The restenosis rate in this population was 58.1%. The frequencies of the three possible genotypes of the ICAM-1 K469E polymorphism were: KK genotype 50.8%, EE genotype 41.9%, and EK genotype 41.9%. Among restenosis patients, the frequency of the KK genotype was 58.3% and the frequency of E allele carriers was 41.7%. Among non-restenosis patients, the frequency of the KK genotype was 40.4%, and the frequency of E allele carriers was 59.6%. The distribution of these two genotype groups between restenosis and non-restenosis patients was significantly different (P = 0.049). Using multivariate logistic regression, the difference between the two groups was more apparent. The odds ratio of KK homozygotes vs E allele carriers was 2.6, with 95% confidence interval 1.2 - 5.8 (P = 0.018). After grading of risk factors, we found that the KK genotype was a stronger predictor of in-stent restenosis in obesity or hyperlipemia patients, with an odds ratio of 9.3 and 3.7, respectively (P < 0.05).
Conclusion:
In our study population, KK homozygotes of the ICAM-1 codon 469 mutation had a higher risk of restenosis after coronary stenting, especially in the case of obese or hyperlipemia patients.
