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Recommendation of modified classification for odontogenic carcinomas
Y Suei1, A Taguchi, K Tanimoto
1Department of Oral and Maxillofacial Radiology, Hiroshima University Dental Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan. suei@hiroshima-u.ac.jp
Medical Hypotheses
|February 21, 2004
Summary
Primary squamous cell carcinoma (SCC) originating from odontogenic epithelium is often called primary intraosseous carcinoma (PIOC). This study suggests renaming it "Odontogenic SCC" as lesions frequently involve more than just bone marrow spaces.
Area of Science:
- Oral pathology
- Oncology
- Dental research
Background:
- Primary intraosseous carcinoma (PIOC) is squamous cell carcinoma (SCC) originating from odontogenic epithelium within bone marrow spaces.
- Odontogenic cells are present in bone marrow, periodontal, and subepithelial soft tissue spaces.
Purpose of the Study:
- To investigate the anatomical distribution of odontogenic SCC.
- To propose a more accurate terminology for these lesions.
Main Methods:
- Survey of 36 SCC lesions of odontogenic origin.
- Analysis of lesion involvement across bone marrow, periodontal, and subepithelial soft tissue spaces.
Main Results:
- Most odontogenic SCC lesions involved two or all three investigated spaces.
- Only one lesion was confined solely to the bone marrow space.
- Early lesions can be localized around teeth or the alveolar crest.
Conclusions:
- The term "intraosseous" may not fully encompass the origin and spread of odontogenic SCC.
- "Odontogenic SCC" is proposed as a more accurate term, reflecting broader tissue involvement.
- SCC of odontogenic origin can arise in periodontal and subepithelial soft tissue spaces.