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Updated: Aug 26, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronisation may reduce all-cause mortality: meta-analysis of preliminary COMPANION data with CONTAK-CD,

Tushar V Salukhe, Konstantinos Dimopoulos, Darrel Francis

    International Journal of Cardiology
    |February 21, 2004
    PubMed

    Insights

    Cardiac resynchronisation therapy (CRT) improves heart failure symptoms. Pooled data now shows CRT significantly reduces all-cause mortality in specific heart failure patients with left bundle branch block.

    Area of Science:

    • Cardiology
    • Medical Devices
    • Clinical Trials

    Background:

    • Biventricular pacing, or cardiac resynchronisation therapy (CRT), is used for chronic heart failure with left ventricular dysfunction.
    • Previous trials showed CRT improved symptoms, exercise capacity, and quality of life, but not all-cause mortality.

    Discussion:

    • The COMPANION study's results, combined with prior data, provide significant evidence for CRT's mortality benefit.
    • Pooled analysis of five randomized controlled trials demonstrates a significant reduction in all-cause mortality (OR, 0.74; 95% CI, 0.56-0.97).

    Key Insights:

    • CRT significantly reduces all-cause mortality in a subset of heart failure patients.
    • This mortality benefit is observed when pooling data from multiple landmark trials.

    Outlook:

    • CRT may become a standard therapy for patients with chronic heart failure and left bundle branch block.
    • Further research could explore optimal patient selection criteria for CRT to maximize survival benefits.

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