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Hepatic capsular retraction in metastatic carcinoma of the breast occurring with increase or decrease in size of
Fiona M Fennessy1, Koenraad J Mortele, Thomas Kluckert
1Department of Radiology, Division of Abdominal Imaging and Intervention, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
AJR. American Journal of Roentgenology
|February 21, 2004
Summary
Hepatic capsular retraction is common in breast cancer liver metastases, often indicating larger lesions. This finding is independent of metastasis number, tumor type, or treatment.
Area of Science:
- Radiology
- Oncology
- Hepatology
Background:
- Hepatic capsular retraction is a morphologic feature observed in liver metastases.
- Its prevalence and clinical significance in breast cancer metastases require detailed evaluation.
Purpose of the Study:
- To determine the frequency of hepatic capsular retraction in breast cancer liver metastases.
- To correlate capsular retraction with metastatic characteristics and patient-specific factors.
Main Methods:
- Retrospective review of abdominal CT scans from 200 women with breast carcinoma.
- Evaluation of 272 CT scans from 58 women with confirmed hepatic metastases.
- Comparison of capsular retraction with metastasis number, size, size change, histopathology, chemotherapy, and receptor status.
Main Results:
- Hepatic capsular retraction was present in 50% of patients with liver metastases.
- Retraction was significantly associated with larger metastases and changes in lesion size (increase or decrease).
- Capsular retraction was not associated with metastasis number, breast tumor histopathology, receptor status, or chemotherapy.
Conclusions:
- Hepatic capsular retraction is a frequent finding in breast cancer liver metastases.
- It is linked to larger lesion size and dynamic changes in metastasis dimensions.
- Capsular retraction is not influenced by tumor characteristics or treatment regimens.