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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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The occurrence of graft-versus-host disease is the major predictive factor for response to donor lymphocyte infusions

Henk M Lokhorst1, Kalung Wu, Leo F Verdonck

  • 1University Medical Center Utrecht, Department of Haematology, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. h.lokhorst@digd.azu.nl

Blood
|February 21, 2004
PubMed

The graft-versus-myeloma (GVM) effect of donor lymphocyte infusions (DLIs) is well established. We now report the outcome of DLI in 54 patients with relapsed myeloma following allogeneic transplantation. Twenty-eight patients (52%) responded, 19 patients (35%) with a partial response and 9 patients (17%) with a complete response. Progression-free and overall survival were 19 and 23 months, respectively. We found that acute and chronic graft-versus-host disease (GVHD) observed in 57% and 47% of patients, respectively, following DLI were the strongest predictors for response. This suggests that targets for GVHD and GVM are identical. In a subgroup analysis, deletion of chromosome 13, as determined by double-color fluorescence in situ hybridization (FISH), had no impact on outcome, indicating that these patients are candidates for early allogeneic transplantation followed by DLI, in case of insufficient response.

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