Related Experiment Video
Updated: Aug 26, 2026

Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice
Christine Jenkins1, John Costello, Linda Hodge
1Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. crj@med.usyd.edu.au
Objective:
To reassess the prevalence of aspirin induced asthma and other issues related to the syndrome.
Data Sources:
Biosis, SciSearch (1990 to March 2002), Embase (1974 to March 2002), Medline (1966 to March 2002), Toxline, Derwent Drug File (1964 to March 2002), Conference Papers Index and Inside Conferences, Int'l Pharmaceutical Abstracts, Pharma-Online (1978 to March 2002).
Selection Criteria:
Study type, patient population, and outcome measures. Review was restricted to respiratory responses to analgesics available without prescription.
Results:
The prevalence of aspirin induced asthma was highest when determined by oral provocation testing (adults 21%, 95% confidence interval 14% to 29%; children 5%, 0% to 14%) than by verbal history (adults 3%, 2% to 4%; children 2%, 1% to 3%). Cross sensitivity to doses of over the counter non-steroidal anti-inflammatory drugs was present in most patients with aspirin induced asthma: ibuprofen, 98%; naproxen, 100%; and diclofenac, 93%. The incidence of cross sensitivity to paracetamol among such patients was only 7%.
Conclusions:
Aspirin induced asthma in adults is more prevalent than previously suggested. When there is a clinical necessity to use aspirin or a non-steroidal anti-inflammatory drug and there is uncertainty about safety, oral provocation testing should be performed.
Related Concept Videos
Asthma-I: Introduction
Asthma I: Introduction
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma III: Clinical Manifestations