Related Experiment Video
Updated: Aug 26, 2026

Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells
Published on: May 22, 2026
Antimycobacterial activity of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids
K Waisser1, K Drazková, J Cizmárik
1Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, 500 05 Hradec Králové, Czechia.
Abstract:
A series of 17 hydrochlorides of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids with the alkoxy group in position 2, 3 or 4 on the phenyl ring, and basic substituents attached to the moiety in position 3, were evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, M. kansasii and M. avium. To describe the structure-antimycobacterial activity relationships (QSAR), an approach based on the Free-Wilson method was employed to express the differences between individual moieties (including propyl and ethyl). The change of ethyl to propyl moiety increases the activity to M. tuberculosis but decreases the antimycobacterial activity to all potentially pathogenic strains under study.
Related Concept Videos
Antimicrobial Effectiveness
Antifungal Agents
Inhibitors of Gram-positive Cell Wall Synthesis
Chemical Agents for Microbial Control
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Acidity and Basicity of Alcohols and Phenols
