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Abnormal human chorionic gonadotropin levels and normal pregnancy outcomes in the ovarian hyperstimulation syndrome

Milroy J Samuel¹, Clemens M Grosskinsky

¹Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Ohio State University, 4830 Knightsbridge Boulevard, Suite E, Columbus, OH 43214, USA.

The Journal of Reproductive Medicine

|February 24, 2004

Abstract

Objective:

To validate whether abnormally rising human chorionic gonadotropin (hCG) levels, in the presence of the ovarian hyperstimulation syndrome (OHSS), may serve to diagnose abnormal gestation.

Study Design:

In an observational, case-control study, the rates of hCG rise after treatment with gonadotropins or assisted reproductive technologies were compared. Cases consisted of 9 women with OHSS. Controls (121 subjects) were matched except that they did not have OHSS. The significance of differences in the slope of the hCG rise was determined by t testing.

Results:

The average doubling time for hCG was 50.4 hours for cases and 38.0 for controls. The slopes of the hCG rise between the groups differed significantly (P = .0015). Pregnancy outcomes were normal for all patients.

Conclusion:

Abnormally rising hCG levels do not predict poor outcome in pregnancies complicated by OHSS and therefore are not helpful in the decision-making process to diagnose ectopic or otherwise compromised pregnancies.

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