Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Energetic depression caused by mitochondrial dysfunction.

Frank Norbert Gellerich1, Sonata Trumbeckaite, Tobias Müller

  • 1Muskellabor der Neurologischen Klinik, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany. frank.gellerich@medizin.uni-halle.de

Molecular and Cellular Biochemistry
|February 24, 2004
PubMed
Summary

Mitochondrial dysfunction, caused by genetic mutations or acute events, leads to cellular energy depletion and disease. Understanding these complex molecular changes requires a multi-level approach to predict clinical outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Propolis as an alternative remedy for the treatment of subclinical mastitis in dairy cows.

Frontiers in veterinary science·2026
Same author

Loss-of-function variants in the CAPN1 activator CD99L2 cause X-linked spastic ataxia.

Nature communications·2026
Same author

Diagnostic Value of Muscle MRI in a Case of Very Late-Onset Becker Muscular Dystrophy.

Clinical neuroradiology·2026
Same author

Changes in the Amino Acid Composition of Bee-Collected Pollen During 15 Months of Storage in Fresh-Frozen and Dried Forms.

Foods (Basel, Switzerland)·2026
Same author

Effect of Fireweed (<i>Chamerion angustifolium</i> L.) Extracts and Oenothein B on Colon Cancer Cells: Impact of Leaf Fermentation on Viability and Mitochondrial Function.

Medicina (Kaunas, Lithuania)·2025
Same author

Compound Muscle Action Potential (CMAP) Amplitude Trajectories and Pattern in Adults with 5q-Spinal Muscular Atrophy Receiving Nusinersen Therapy: A Multicenter, Binational Observational Study.

European journal of neurology·2025

Area of Science:

  • Cell Biology
  • Biochemistry
  • Genetics

Background:

  • Mitochondria are crucial for cellular energy (ATP) production, biosynthesis, and calcium signaling.
  • Mitochondrial dysfunction, stemming from mt-genome mutations or acute insults, is implicated in numerous diseases.
  • The link between molecular changes and clinical conditions is complex, necessitating multi-level investigations.

Purpose of the Study:

  • To review classical bioenergetic mechanisms underlying mitochondrial impairment.
  • To explore how mitochondrial dysfunction contributes to cellular energetic depression.
  • To highlight the importance of a multi-level approach in studying mitochondrial diseases.

Main Methods:

  • Literature review focusing on bioenergetic mechanisms.

Related Experiment Videos

  • Application of Metabolic Control Theory to understand enzyme activity effects.
  • Analysis of molecular and functional changes in mitochondria.

    • Main Results:

    • Mitochondrial impairments include decreased adenine nucleotides, membrane leakiness, and reduced respiratory chain enzyme activity.
    • These impairments lead to depressed cellular energy metabolism, notably decreased cytosolic phosphorylation potentials.
    • Metabolic Control Theory aids in interpreting the impact of mutations on mitochondrial function.

    Conclusions:

    • Mitochondrial dysfunction significantly impacts cellular energy metabolism.
    • A multi-level approach is essential for comprehending mitochondrial diseases.
    • Understanding bioenergetic mechanisms is key to addressing diseases linked to mitochondrial impairment.