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Epithelial-mesenchymal interactions in the developing lung.

John M Shannon1, Brian A Hyatt

  • 1Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. john.shannon@chmcc.org

Annual Review of Physiology
|February 24, 2004
PubMed
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Lung development relies on crucial signaling between epithelial and mesenchymal cells. Key pathways like FGF, Shh, Wnt, and BMP4 orchestrate embryonic lung growth, patterning, and differentiation.

Area of Science:

  • Developmental biology
  • Cell signaling
  • Embryology

Background:

  • Normal lung development requires precise communication between endodermal epithelium and splanchnic mesoderm.
  • This epithelial-mesenchymal interaction is mediated by numerous signaling factors with strict temporal and spatial control.

Purpose of the Study:

  • To review the factors regulating embryonic foregut formation.
  • To discuss experimental evidence highlighting the importance of tissue interactions in lung patterning and differentiation.
  • To detail the roles of specific signaling systems in mediating lung epithelial-mesenchymal interactions.

Main Methods:

  • Literature review of classical embryology experiments.
  • Analysis of signaling pathways involved in lung development.

Related Experiment Videos

  • Focus on fibroblast growth factors (FGFs), sonic hedgehog (Shh) and Gli genes, Wnt genes and beta-catenin, and BMP4.

    • Main Results:

    • Identified key signaling pathways regulating embryonic lung development.
    • Demonstrated the critical role of epithelial-mesenchymal interactions in lung patterning and differentiation.
    • Detailed the specific functions of FGFs, Shh/Gli, Wnt/beta-catenin, and BMP4 in mediating these interactions.

    Conclusions:

    • Epithelial-mesenchymal interactions are fundamental for normal lung development.
    • Specific signaling pathways (FGF, Shh, Wnt, BMP4) are essential mediators of these interactions.
    • Understanding these pathways provides insights into lung morphogenesis and potential therapeutic targets.