Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cytochrome bc1 complex: function in the context of structure.

Antony R Crofts1

  • 1Department of Biochemistry, and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. a-crofts@life.uiuc.edu

Annual Review of Physiology
|February 24, 2004
PubMed
Summary

The bc1 complex is crucial for energy production and its dysfunction causes mitochondrial myopathies and aging. Understanding its mechanism and inhibitors aids in developing therapies and understanding age-related diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The modified Q-cycle: A look back at its development and forward to a functional model.

Biochimica et biophysica acta. Bioenergetics·2021
Same author

Dissecting the pattern of proton release from partial process involved in ubihydroquinone oxidation in the Q-cycle.

Biochimica et biophysica acta. Bioenergetics·2018
Same author

The Q-Cycle Mechanism of the bc<sub>1</sub> Complex: A Biologist's Perspective on Atomistic Studies.

The journal of physical chemistry. B·2017
Same author

New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans.

Worm·2016
Same author

In photosynthesis, oxygen comes from water: from a 1787 book for women by Monsieur De Fourcroy.

Photosynthesis research·2016
Same author

Correction to The Semiquinone at the Q(i) Site of the bc1 Complex Explored Using HYSCORE Spectroscopy and Specific Isotopic Labeling of Ubiquinone in Rhodobacter sphaeroides via (13)C Methionine and Construction of a Methionine Auxotroph.

Biochemistry·2015

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Respiration

Background:

  • The bc1 complex (cytochrome bc1 complex) is a key component of cellular respiration, essential for ATP synthesis via the Q-cycle mechanism.
  • Mutations in bc1 complex subunits lead to mitochondrial myopathies and are implicated in cellular aging due to reactive oxygen species production.

Purpose of the Study:

  • To review recent advances in understanding the bc1 complex mechanism.
  • To correlate this understanding with its role in aging and disease.
  • To discuss the implications of structural studies on bc1 complex inhibitors.

Main Methods:

  • Review of recent structural and mechanistic studies of the bc1 complex.
  • Analysis of the Q-cycle mechanism and its relation to superoxide production.

Related Experiment Videos

  • Examination of inhibitor binding and resistance mechanisms.

    • Main Results:

    • The Q-cycle mechanism couples electron transfer to proton gradient generation, but can also produce damaging superoxide radicals.
    • Dysfunctional bc1 complexes contribute to mitochondrial myopathies and cellular aging.
    • Structural insights reveal inhibitor binding sites and mechanisms of resistance.

    Conclusions:

    • Understanding the bc1 complex mechanism is vital for addressing mitochondrial diseases and aging.
    • Inhibitors targeting the bc1 complex have therapeutic and agronomic potential.
    • Structural biology provides a basis for designing new inhibitors and understanding drug resistance.