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Transverse Myelitis: pathogenesis, diagnosis and treatment
Chitra Krishnan1, Adam I Kaplin, Deepa M Deshpande
1Department of Neurology, Johns Hopkins Transverse Myelitis Center, 600 N. Wolfe Street Pathology 627C, Baltimore MD 21287-6965, USA. ckrishn1@jhmi.edu
Frontiers in Bioscience : a Journal and Virtual Library
|February 24, 2004
Summary
Transverse Myelitis (TM) is a spinal cord injury caused by immune system dysfunction. This review covers TM classification, diagnosis, and treatment strategies for better patient management.
Area of Science:
- Neurology
- Immunology
- Clinical Medicine
Background:
- Transverse Myelitis (TM) is a neurological disorder affecting the spinal cord.
- It involves immune-mediated neural injury, leading to weakness, sensory changes, and autonomic dysfunction.
- TM can be isolated or associated with other systemic or central nervous system diseases.
Purpose of the Study:
- To summarize recent classification and diagnostic schemes for Transverse Myelitis.
- To provide a framework for the acute management of TM patients.
- To review current concepts on TM's natural history, immunopathogenesis, and treatment.
Main Methods:
- Literature review of recent classification and diagnostic schemes.
- Synthesis of current knowledge on TM's natural history and immunopathogenesis.
- Analysis of established and emerging treatment strategies for TM.
Main Results:
- Recent schemes offer a structured approach to TM diagnosis and acute management.
- Understanding TM's diverse origins (idiopathic, MS-related, systemic disease-related) is crucial.
- Evolving insights into immunopathogenesis inform treatment development.
Conclusions:
- Accurate classification and diagnosis are key for effective TM management.
- Further research into TM's natural history and immunopathogenesis is needed.
- Optimized treatment strategies aim to improve outcomes for patients with Transverse Myelitis.