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Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
Transverse Myelitis: pathogenesis, diagnosis and treatment
Chitra Krishnan1, Adam I Kaplin, Deepa M Deshpande
1Department of Neurology, Johns Hopkins Transverse Myelitis Center, 600 N. Wolfe Street Pathology 627C, Baltimore MD 21287-6965, USA. ckrishn1@jhmi.edu
Abstract:
Transverse Myelitis (TM) is a clinical syndrome in which an immune-mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations and autonomic dysfunction. TM may exist as part of a multi-focal CNS disease (e.g. MS), multi-systemic disease (e.g. systemic lupus erythematosus), or as an isolated, idiopathic entity. In this article, we will summarize recent classification and diagnostic schemes (1), which provide a framework for the acute management of patients with TM. Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM.
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