Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predicting the response to lung volume reduction surgery using scintigraphy.

Norihisa Shigemura1, Akinori Akashi, Tomoyuki Nakagiri

  • 1Division of General Thoracic Surgery, Takarazuka Municipal Hospital, Hyogo, Japan. n-shige@blue.ocn.ne.jp

Asian Cardiovascular & Thoracic Annals
|February 24, 2004
PubMed
Summary

Quantitative scintigraphy effectively assesses lung volume reduction surgery efficacy in emphysema patients. Lung uniformity, a key marker, predicts outcomes and shows differential improvement based on emphysema subtype.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Celebrating professor Yasunaru Kawashima's award of the order of culture: first recipient as cardiac surgeon.

General thoracic and cardiovascular surgery·2026
Same author

Early predictors and outcomes of mechanical circulatory support use during single lung transplant for secondary pulmonary hypertension: A large single-center experience.

JHLT open·2026
Same author

Celebrating Professor Yasunaru Kawashima's Award of the Order of Culture: First Recipient as Cardiac Surgeon.

General thoracic and cardiovascular surgery·2026
Same author

Letter to the editor of general thoracic and cardiovascular surgery : Celebrating professor Yasunaru Kawashima's award of the Order of Culture: first recipient as cardiac surgeon.

General thoracic and cardiovascular surgery·2026
Same author

Immune gene correlation networks differentiate both chronic lung allograft dysfunction and survival.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Reframing surgical decision-making when treating severe pulmonary hypertension: Beyond the binary of lungs alone vs combined heart-lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2025

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Surgical Innovation

Background:

  • Emphysema significantly impacts lung function and quality of life.
  • Lung volume reduction surgery (LVRS) is a treatment option for severe emphysema.
  • Accurate methods to assess LVRS efficacy are crucial.

Purpose of the Study:

  • To evaluate quantitative scintigraphy with novel markers for assessing and predicting LVRS efficacy.
  • To correlate scintigraphic markers with pulmonary function tests (PFTs) post-LVRS.
  • To investigate the relationship between emphysema histopathology and scintigraphic marker improvement.

Main Methods:

  • Quantitative ventilation/perfusion scintigraphy performed on 50 severe emphysema patients before and 6 months after LVRS.
  • Measurement of area ratio and lung uniformity markers.

Related Experiment Videos

  • Correlation of markers with PFTs and determination of histopathological subtypes.

    • Main Results:

    • Scintigraphic markers, particularly lung uniformity, strongly correlated with improvements in forced expiratory volume in 1 second (FEV1).
    • Lung uniformity showed significantly greater improvement in centrilobular emphysema compared to panlobular emphysema.
    • Quantitative scintigraphy provided a reflection of surgical efficacy and predictive value.

    Conclusions:

    • Quantitative scintigraphy offers a reliable method to assess and predict LVRS outcomes in emphysema.
    • The lung uniformity marker provides mechanistic insights into differential surgical benefits across emphysema subtypes.
    • This technique aids in understanding surgical efficacy and patient selection for LVRS.