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Updated: Aug 26, 2026
Establishment of Deep Hypothermic Circulatory Arrest in Rats
Published on: December 16, 2022
Extensive thoracoabdominal aortic aneurysm repair using deep hypothermic bypass and circulatory arrest
Hiroyuki Nishi1, Satoru Miyamoto, Hirokazu Minamimura
1Department of Cardiovascular Surgery, Osaka General City Hospital, Osaka, Japan. nishi24@jc4.so-net.ne.jp
Insights
Deep hypothermic cardiopulmonary bypass with circulatory arrest is safe and effective for thoracoabdominal aortic aneurysms. This technique offers significant renal protection, though respiratory complications require attention.
Area of Science:
- Cardiovascular Surgery
- Vascular Surgery
- Aortic Aneurysm Research
Background:
- Extensive thoracoabdominal aortic aneurysms present complex surgical challenges.
- Current surgical strategies require evaluation for safety and efficacy.
Purpose of the Study:
- To assess the safety and utility of deep hypothermic cardiopulmonary bypass with circulatory arrest.
- To compare outcomes between hypothermic and normothermic bypass for thoracoabdominal aortic aneurysms.
Main Methods:
- Retrospective review of 17 patients with Crawford type I and II thoracoabdominal aortic aneurysms.
- Comparison of outcomes between a hypothermic group (n=8) and a normothermic group (n=9).
Main Results:
- In-hospital mortality was comparable (12.5% vs 11.1%).
- Hypothermic group showed significantly shorter cardiopulmonary bypass times and reduced postoperative renal dysfunction.
- Postoperative creatinine levels were significantly lower in the hypothermic group.
Conclusions:
- Deep hypothermic cardiopulmonary bypass with circulatory arrest is a safe and effective technique for thoracoabdominal aortic aneurysms.
- The technique demonstrates significant renal protection benefits.
- Respiratory complications remain a concern requiring further management strategies.
Abstract:
We sought to evaluate the safety and usefulness of deep hypothermic cardiopulmonary bypass with intervals of circulatory arrest for extensive thoracoabdominal aortic aneurysms. Between March 1994 and December 2002, 17 patients with Crawford type I and II were reviewed retrospectively. The patients were divided into two groups: group H (hypothermic circulatory arrest, n = 8) and group N (normothermic cardiopulmonary bypass, n = 9). In group H, in-hospital mortality was 12.5%, and that in group N was 11.1%. Operation times were similar between the two groups though the cardiopulmonary bypass time was significantly shorter in group N than in group H (p < 0.05). Postoperative paraplegia occurred in 1 patient of group N. Postoperative renal dysfunction occurred in none of group H except in 1 preoperative dialysis case, whilst it occurred in 6 patients of group N. Postoperative creatinine levels were significantly higher in group N than in group H. Three cases in group H required tracheostomy. Our experience with hypothermic cardiopulmonary bypass and circulatory arrest for diffuse type thoracoabdominal aortic aneurysm confirms the safety and efficacy of this technique. Although respiratory complications remain a problem, the technique is considered to be effective for renal protection.
