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Updated: Aug 26, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
Glucuronidation and the UDP-glucuronosyltransferases in health and disease
Peter G Wells1, Peter I Mackenzie, Jayanta Roy Chowdhury
1Faculty of Pharmacy and Department of Pharmacology, University of Toronto, Ontario, Canada.
Abstract:
This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.
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