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Probable adverse reaction to a pharmaceutical excipient.
C M Hall1, D W A Milligan, J Berrington
1Pharmacy Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 24, 2004
Summary
Adverse drug reactions are common, but data on children is scarce. This report details a specific adverse reaction in a child caused by an excipient in clindamycin injection.
Area of Science:
- Pediatric Pharmacology
- Clinical Pharmacy
- Drug Safety
Background:
- Adverse drug reactions (ADRs) are a significant concern in healthcare.
- While ADRs are recognized, specific incidence data in pediatric populations remains limited.
- Pharmaceutical excipients, though often considered inert, can contribute to adverse events.
Observation:
- This case report focuses on an adverse reaction observed in a pediatric patient.
- The reaction was specifically linked to an excipient present in clindamycin injection.
- Detailed clinical observations of the reaction were documented.
Findings:
- A specific adverse reaction was identified in a child receiving clindamycin injection.
- The reaction was attributed to a pharmaceutical excipient within the clindamycin formulation.
- This highlights the potential for excipients to cause pediatric adverse drug reactions.
Implications:
- This case underscores the need for greater awareness of excipient-related adverse reactions in children.
- Further research into the safety profiles of pharmaceutical excipients in pediatric use is warranted.
- Clinicians should consider excipient composition when evaluating pediatric adverse drug reactions.