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Updated: Aug 26, 2026

The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
[Genetic polymorphism of biotransforming enzymes and genotoxic effects of styrenes]
G De Palma1, P Mozzoni, E Scotti
1Laboratorio di Tossicologia Industriale, Centro Studi e Ricerche ISPESL presso l'Università di Parma.
Abstract:
A cross-sectional study was carried out on laminators producing glass-fibre reinforced plastics, to evaluate the role of genetic polymorphism of xenobiotic metabolising enzymes on the genotoxicity of styrene. Clastogenic effects, evaluated by the micronucleus test, are related with end-of-shift urinary concentration of 4-vinylphenol and seem to be modulated by NQO1 polymorphism; aneuploidogenic effects, evaluated by the identification of centromers in micronuclei using the fluorescence in situ hybridisation technique with a pancentromeric probe, are related with before-shift urinary levels of mandelic and phenylglyoxylic acids and seem to be modulated by the GSTM1 polymorphism.
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