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[Comparative in vitro study of various titanium compounds on the immune system]
1Sezione di Medicina del Lavoro, Allergologia ed Immunologia Clinica del Dipartimento di Medicina e Scienze dell'Invecchiamento, Università G. D'Annunzio, Chieti.
Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia
|February 26, 2004
Abstract:
The "in vitro" immune effects of different Ti compounds on peripheral blood mononuclear cells (PBMC) were determined. The results show that Ti dioxide is not immunotoxic; Ti oxalate is strongly immunotoxic; titanocene inhibits cytokine release but not PBMC proliferation, while Ti ascorbate inhibits TNF-alpha release from PBMC but not that of IFN-gamma. The results show that Ti toxicity depends on speciation.