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Updated: Aug 26, 2026
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
[Study of reproductive health risks in Sicily. Congenital malformations and exposure to EDCs: a case-control study
P Carbone1, F Giordano, S Bianca
1Dipartimento di Biologia Animale e dell'Uomo, Università degli Studi di Roma La Sapienza.
Introduction:
The incidence of Congenital Malformations may represent an early biological indicator for human toxicity to environmental and occupational contaminants. SCIENTIFIC OBJECTIVE: We are in the process of exploring the relation between various potential sources of parental periconceptional pregnancy exposures to Endocrine Disrupting Chemicals (EDCs) and selected Congenital Malformations in offspring.
Materials And Methods:
The low incidence of Congenital Malformations leads to an epidemiological "Case-Control" study. The areas of the study are the Ragusa Municipalities and the south-east Siracusa Municipalities. We are conducting personal interviews with parents of about 100 cases with orafacial clefts or male genital malformations and 200 nonmalformed controls. The infants for the study were selected from those born during 1998-2002 in these areas. The more important variables considered are: 1--parental occupation and workplace exposures. 2--relevant confounders and recall bias. The analysis of the data will use the classical approach of case-control study (matching procedure), comparing risk factor frequency between cases and controls.
Conclusions:
The results of the study will allow to clarify the relationship between parental exposure to EDCs compounds and human reproduction.
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