[Expression of CD44v6 and E-cadherin in prostate carcinoma and metastasis of prostate carcinoma]
Related Experiment Video
Updated: Aug 26, 2026
Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging
Published on: April 8, 2016
Huaping Gu1, Peizhong Shang, Cuiling Zhou
1Department of Pathology, 251st Hospital of PLA, Zhangjiakou, Hebei 075000, China. guhuapingzjk@sohu.com
Objective:
To study the expression of CD44v6 and E-cadherin(ED) in prostate carcinoma in relation to the metastasis of prostate carcinoma.
Methods:
The expression of CD44v6 and ED in 45 cases of prostate carcinoma was studied with immunohistochemical technique.
Results:
The positive expression rates of CD44v6 and ED in prostate carcinoma were 77.8% and 48.9%, respectively. The high level expression of CD44v6 and the low level expression of ED were positively correlated with differentiation, clinical staging and metastasis of prostate carcinoma (P < 0.05). The expression of CD44v6 was negatively correlated with ED(r = -0.58, P < 0.005).
Conclusions:
The expression of CD44v6 and ED protein might be a useful marker for prostate carcinoma in evaluating the biological behavior and prognosis of the tumor.
Related Concept Videos
01:19Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
02:30Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...