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Updated: Aug 26, 2026
Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
Published on: December 20, 2019
[Expression changes of tau protein and microtubule-associated proteins in testis intersitium of rats]
Zilong Liu1, Gang Wang, Wanhong Zhang
1Family Planning Institute, Tongji Medical College of Huazhong Science and Technology University, Wuhan, Hubei 430030, China.
Objective:
To examine the expression of the tau protein and microtubule-associated proteins in the testis interstitium of aged and young rats.
Methods:
Sprague-Dawley male rats were divided into a young group(6 months, n = 10) and an aged group(28 months, n = 10). The two steps immunohistochemistry method with the antibody against tau protein and MAP alpha was performed on the testis tissues of the rats.
Results:
The results showed that the immunoreactive cells of tau protein of the testis interstilial of the aged rats obviously increased(P < 0.001) than those of the young, while the immunoreactive cells of the microtubule-associated proteins decreased(P < 0.01) in the aged.
Conclusion:
The changes in the expression of the tau protein and microtubule-associated proteins may be related to the aging process of the testis.
