Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Matrix effect in oleate micelles-vesicles transformation.

Silvia Rasi1, Fabio Mavelli, Pier Luigi Luisi

  • 1Institute of Polymers Swiss Federal Institute of Technology (ETH-Z) Zürich, Switzerland.

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
|February 26, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissecting clonal hematopoiesis in the myeloid compartment of chronic lymphocytic leukemia and Richter transformation.

HemaSphere·2026
Same author

Unraveling the Epigenetic Landscape of Mature B Cell Neoplasia: Mechanisms, Biomarkers, and Therapeutic Opportunities.

International journal of molecular sciences·2025
Same author

Integration of [<sup>18</sup>F]FDG-PET radiomics with liquid biopsy improves outcome prediction in newly diagnosed diffuse large B-cell lymphoma.

Leukemia·2025
Same author

Molecular clustering on ctDNA improves the prognostic stratification of patients with DLBCL compared with ctDNA levels.

Blood advances·2025
Same author

Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement.

Leukemia·2024
Same author

XPO1 mutations identify early-stage CLL characterized by shorter time to first treatment and enhanced BCR signalling.

British journal of haematology·2023

The formation of oleic acid/oleate vesicles from micelles is influenced by pre-existing vesicles, a phenomenon termed the matrix effect. This study investigates how different vesicle types affect vesicle formation and size distribution.

Area of Science:

  • Biochemistry
  • Origin of Life Studies
  • Materials Science

Background:

  • The formation of self-assembled molecular structures like vesicles is crucial for understanding the origin of life.
  • Oleate vesicles, formed from fatty acids, serve as a relevant model system for prebiotic chemistry.
  • Fatty acids are considered key building blocks for early life structures.

Purpose of the Study:

  • To investigate the pH-induced transition from oleate micelles to oleic acid/oleate vesicles.
  • To explore the influence of pre-formed vesicles, termed the matrix effect, on this transition.
  • To compare the effects of pre-added 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (POPC) liposomes and oleic acid/oleate vesicles on vesicle formation.

Main Methods:

  • Inducing vesicle formation through pH changes.

Related Experiment Videos

  • Utilizing pre-formed POPC liposomes and oleic acid/oleate vesicles as model systems.
  • Analyzing the impact of these pre-added systems on the kinetics and final size distribution of newly formed vesicles.

    • Main Results:

    • The presence of pre-formed vesicles significantly influences the rate and outcome of oleic acid/oleate vesicle formation.
    • Distinct differences were observed in the matrix effect when comparing POPC liposomes versus oleic acid/oleate vesicles.
    • The study elucidates the specific roles of different vesicle types in modulating self-assembly processes.

    Conclusions:

    • The matrix effect is a critical factor in the self-assembly of oleic acid/oleate vesicles.
    • The choice of pre-existing vesicle structure impacts the efficiency and characteristics of de novo vesicle formation.
    • Understanding these self-assembly dynamics provides insights into prebiotic molecular evolution.